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Deletion of exon 20 of the Familial Dysautonomia gene Ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethality.

Familial Dysautonomia (FD) is an autosomal recessive disorder that affects 1/3,600 live births in the Ashkenazi Jewish population, and leads to death before the age of 40.The disease is characterized by abnormal development and progressive degeneration of the sensory and autonomic nervous system.A single base pair substitution in intron 20 of the I

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Hyperconcentrated flows shape bedrock channels

Abstract Geomorphological evidence of incised bedrock channels is widespread in all mountain landscapes worldwide.However, the processes controlling incision and gorge formation in bedrock have not directly been observed in an actualistic way.Here, we show a LiDAR change detection deciphering the erosive power of a 60,000 m3 hyperconcentrated flow

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